ABSTRACT

The objectives of this study were to perform investigative tape stripping model using liposomal formulations to evaluate the skin permeation of drug using these different liposome compared to free drug. The effect of number of strips, surface charge and incubation time on permeability of drug was estimated. Different gamma oryzanol (OZ) loaded liposomes were formulated using REV method soy PC and Cholesterol. Release of OZ was observed from the liposomes up to 6 h. Photosensitive and conventional liposomes demonstrated significant (p ? 0.05) permeation into the skin compared to the free drug solution. Blockage of the hair follicles may result in reduction in the extent and intensity of drug permeation through the skin layers. Overall, liposomal formulations proved to be an ideal carrier for this study. Surface charge and incubation time played vital roles in the extent of permeation. Keywords: Tape stripping, Skin Permeation, Liposomes, Gamma Oryzanol
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6913.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6913