ABSTRACT

Ulcerative colitis is a global disease having increasing incidence and worldwide prevalence. Murraya koenigii has been used in various conditions like asthma, diabetes, inflammation etc. & the present study was aimed to study the effect of ethanolic extract of leaves of Murraya koenigii (EEMK) in TNBS induced ulcerative colitis in Sprague dawley rats. 2, 4, 6 – trinitro benzene sulphonic acid (TNBS) (20 mg) was introduced intra-rectally in all groups on 1st day except normal control group. Standard control group received sulphasalazine (120 mg/kg) p.o & treatment group received different dose of EEMK (125, 250 & 500 mg/kg) for consecutive seven days. Data findings of present study revealed that EEMK showed significant improved (P<0.05) disease parameters like body weight, stool consistency & rectal bleeding, colon length as compared to disease control group. Treatment with EEMK (250 & 500 mg/kg) shown significantly improved (P<0.05) DAI & CMDI score as compared to DC group. Significantly higher antioxidant parameters like SOD & Catalase and lower NO, MPO & LPO level (P<0.05) were observed in animals treated with EEMK (500 mg/kg) as compared to disease control animals. Present study has revealed that ethanolic extract of leaves of Murraya koenigii is having beneficial and curative effect in TNBS induced ulcerative colitis in rats. LCMS data confirmed presence of mahanine, mahanimbine & ?-sitosterol in ethanolic extract of leaves of Murraya koenigii which might be responsible for its protective effect in ulcerative colitis. Keywords: Curry leaves; Ethanolic extract of leaves of Murraya koenigii; Sulphasalazine; TNBS; Ulcerative colitis
Publication date: 01/03/2023

https://ijbpas.com/pdf/2023/March/MS_IJBPAS_2023_6569.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.3.6569