ABSTRACT

Background: Pathogenic bacterial species of humans with polymicrobial infections frequently show synergistic interactions that increase colonization and survivability. Pseudomonas aeruginosa and Staphylococcus aureus are the two most popularly known skin infections causing pathogenic bacteria, monoculture infection of particular species are less chronic rather than their co-infection of interspecies. Skin infections are generally cured by topical gel as a first-line treatment because of their non-sticky texture, good stability and aesthetic value. Methods: Medicinal oils were selected and incorporated into a gel base to evaluate their physicochemical properties such as pH, viscosity, spreadibility and extrudability and evaluate antibacterial potential against selected bacterial species. Results: The physicochemical evaluation observed for three formulations could be easily washable; F3 shows high viscosity and extrudability while F2 shows high spreadibility. It is observed that the F3 formulation shows high antibacterial potential. Conclusion: This study was to formulate a polyherbal topical gel containing Coconut oil, Neem leaves ethanolic extract and Tea tree oil to treat skin related fetal infections causing by Pseudomonas aeruginosa and Staphylococcus aureus, which is as effective as marketed conventional gel. Keywords: Pseudomonas aeriginosa, Staphylococcus aureus, Extrudability, Spreadibility, Viscosity
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6898.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6898