ABSTRACT

Whenever some drugs which are not targeted are systemically administrated, they do not show desired efficacy and acceptable toxicity. Hence, the development of targeting approaches for site targeting drug delivery helps in reducing the toxicity and thereby improved therapeutic efficacy, unlike the non-targeted drugs. The literature studies that are done during the past years had understood the factors that are limiting the tissue targeting drug delivery and made some approaches that help in targeted drug delivery. Some of them include carbohydrates-based, protein-based, pathogen-based, mammalian cell membrane-based, small molecules-based, monoclonal antibody-based, Integrin-based, aptamer-based and we discussed how these approaches have a great potential in reducing/avoiding the level of toxicities and improving the quality of life and patient well-being. Keywords: Tissue targeting drug delivery, targeting approaches, carbohydrates, monoclonal antibody, aptamer
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6892.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.2.6892