ABSTRACT

Siddha medicines mainly depend on the natural resources for medicine preparation, in which higher order medicines like Parpam, Chenduram, Kattu etc., are more effective but which are not validated in scientific aspect. In this study, the anti-inflammatory activity of Ayaveera Chenduram (AVC) was evaluated in a carrageenan-induced rat paw edema method and compared with that of indomethacin. Rats treated with indomethacin (10 mg/kg, p.o.) and AVC (200 and 400 mg/kg, p.o.) showed a significant reduction in carrageenan-induced paw edema. Indomethacin inhibited the edema by 54.15 % and 66.54% at 2 and 3 h after carrageenan injection, respectively. The inhibitory effect of AVC began at 2 h or later after carrageenan injection depending upon the administered dose. Low doses of AVC (23 mg/kg) gave significant inhibitory effects of 30.76-53.95%, and higher doses of AVC (46 mg/kg) caused significant inhibition at levels of 35.29-58.63%. The reduction of edema by indomethacin and AVC at 2 h or more after carrageenan injection suggests that both compounds produce anti-inflammatory effects in the second phase of edema, indicating inhibition of prostaglandin synthesis. Therefore, it can be inferred that the inhibitory effect of Ayaveera Chenduram downregulating the proinflammatory cytokines pathway. They were found to be effective and (**p<0.01) significantly decreased the inflammatory reactions.The present results suggest that Ayaveera Chenduram suppresses carrageenan-induced paw edema, thus, confirming the anti-inflammatory property of Ayaveera Chenduram. Keywords: Anti-inflammation, Paw edema, Carrageenan, Ayaveera Chenduram
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6880.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6880