ABSTRACT

Introduction: Indian Medicinal plants have been used from long centuries back for the treatment of diabetes mellitus. The literature review reported the antidiabetic activity of S. oblonga Linn. stem and E. littorale Blume. aerial part against various models of diabetes. Materials and Methods: The present study evaluated the combined in-vitro antidiabetic potential of aqueous extract on glucose adsorption capacity, glucose diffusion using dialysis bags and glucose uptake by yeast cells. Results: The extracts adsorption capacity was related to the molar concentration of glucose. The glucose bound ratio was 73.21, 81.11, 94.09 and 97.45 with aqueous extract of S. oblonga, E. littorale, combined S. oblonga & E. littorale and standard drug (Acarbose), respectively from a 100 mM glucose concentration solution. The results of in-vitro glucose diffusion studies showed that the aqueous extracts decrease the transport of glucose in dose dependent manner. The combined extract of plants had showed comparable glucose adsorption to acarbose. A significant difference (p<0.05) in the diffusion of glucose were observed when result compared with individual extract of plants. Further, dose dependent effects were found in glucose uptake by yeast cells assay, but there was an inverse relationship between the concentration of glucose and dose of plant extracts. Conclusion: The present study indicates that the aqueous extract of S. oblonga and E.littorale is able to adsorb glucose molecules and inhibit glucose transport, which makes them less available for absorption in the intestine. Further, research has to be carried out in order to find out active biochemicals to facilitate their use to control hyperglycemia. Keywords: Medicinal plants, Glucose transport, Glucose adsorption, Yeast cell, Antidiabetic
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6858.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6858