ABSTRACT

The current review paper focuses on using several analytical approaches to estimate Lamivudine and their combination of drugs. Lamivudine is used to treat HIV and Hepatitis B infection. It acts as a competitive inhibitor of the HBV DNA polymerase and blocks viral replication by inhibiting the viral polymerase by chain termination. Lamivudine and its combinations are estimated by using various analytical techniques like UV-Visible spectrophotometer, High Performance Liquid Chromatography (HPLC), Liquid chromatography –Tandem mass spectrophotometry (LC-TMS), High Performance Thin Layer Chromatography (HPTLC). This review makes clear about the usage of precise solvents for the estimation of lamivudine and its combinations. Keywords: Lamivudine, UV, HPLC, HPTLC, LC-TMS
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6849.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6849