ABSTRACT

Parkinson’s disease (PD) is second largest neurodegenerative disorder which is seen mostly in elder people than the younger ones. PD is mainly caused by depletion of dopaminergic neurons in substantia nigra part of the brain and formation of Lewis bodies. The exact cause for PD is not known but genetic mutation, mitochondrial dysfunction, oxidative stress and protein misfolding are few causes for PD. PD is basically manifested by Rigidity, tremor, bredykinesia, Postural disability, Depression and anxiety, freezing and sleep disturbances. It is more common to occur in man than in woman but mortality rate is higher in woman than in men. There are almost 7 million cases of PD worldwide. Some available drug treatments for PD are dopaminergic (pramipexxol), non-dopaminergic (NMDA antagonist), Psychotropic Treatment (Trazodone, SSRI, SNRI), Tremor (Levodopa, dopamine agonists), Deep Brain stimulation surgery etc. Other than this, various phytochemicals have been explored to treat PD such as rosmerinic acid, curcumin, resveratrol, baicalein, quarcetin and naringenin. Till now no exact treatment has been discovered but symptomatic treatment is been carried out to treat PD symptomatically, numerous studies are in progress to discover appropriate treatment for PD. In this review we try to collect information regarding various phytochemicals which are explored in the management of Parkinson’s disease by using animal models. Keywords: Parkinson’s disease; Phytochemicals; Neurodegenerative disorder; Dopaminergic neurons; Oxidative stress
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_6828.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6828