ABSTRACT

Cancer, which is a global threat, is one of the main causes of death worldwide. It is also considered a global public health problem. Breast cancer is a complicated disease and therefore the second most popular type. Currently, more efforts are being made to research new drugs and combination therapies to achieve a synergistic effect in cancer therapy. Herein, MDA-MB-231 breast cancer cells were treated with SAHA, ERL, and their combination for 24 h, and the cell cytotoxicity was evaluated using MTT-assay. Cell cycle distribution and apoptosis level were also investigated. It was shown that the combination of ERL and SAHA synergistically induce cell cytotoxicity and strongly induce apoptosis, cell cycle arrest, and cause upregulation in the level of P21 and PARP at the selected concentration compared with the drugs alone after 24 h. In conclusion, there is a synergistic effect between ERL and SAHA with increasing PARP and P21 gene-level, thereby playing a therapeutic role in killing breast cancer cells. Keywords: MDA-MB-231; P21; PARP; SAHA; ERL
Publication date: 01/02/2023

https://ijbpas.com/pdf/2023/February/MS_IJBPAS_2023_68141.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.2.6814