ABSTRACT

The main objective of the present study is to formulate dasatinib loaded nanoparticles to enhance the solubility and dissolution rate of the drug. The nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and TPP. The prepared nanoparticles were evaluated for particle size, shape, charge, encapsulation efficiency and in vitro drug release. The optimized drug loaded nanoparticles showed the size of 125 ± 4mn with PDI 0.25 ± 0.05, potential of +40 ± 2mV, encapsulation efficiency of 65.5 ± 1.2% and the drug release of 79 % with an initial burst effect of 22% in one hour followed by sustained release up to 24 hrs. These preliminary results demonstrate that the possibility of delivering hydrophobic drugs to target with enhanced encapsulation efficiency and dissolution rate Keywords: Chitosan, Hydrophobic drugs, Nanoparticles, cancer
Publication date: 01/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_59331.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.5933