ABSTRACT

Background: Naratriptan and Zolmitriptan are drugs used for the treatment of migraine headaches. Zolmitriptan and Naratriptan is a group of medicines known as serotonin 5-HT1B/1D receptor agonist. Objective: To develop analytical methods suitable for validation of Naratriptan and Zolmitriptan by UV spectrophotometric methods as per the ICH guidelines. Methods: For UV-Method water: glycerol (1% v/v) is used as solvent as well as Methanol water used as solvent. Solution of drugs were scanned in spectrophotometer in the range 200-400nm. Results: In UV Method the wavelength was chosen for analysis of Zolmitriptan 238nm, Naratriptan 328nm. The Linearity of proposed methods found to be Zolmitriptan 1-10?g/mL and Naratriptan 1-12?g/mL LOC and LOQ values shows that the method was sensitive and specific. %RSD values found to be <2. The R2 values were found to be >0.99. Keywords: Naratriptan, Zolmitriptan, Methanol, UV, Accuracy
Publication date: 01/01/2023

https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6773.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.1.6773