Keloid or Che.loid, [kee-loid]
Keloid are abnormal scars that, if not treated appropriately, can cause substantial emotional and
physical distress in patients. Scars are prone to recurrence and rarely regress. They are unpleasant,
can cause pain, itching, discomfort, and can have a negative impact on one’s quality of life. Keloid
development is influenced by both hereditary and environmental factors. Predisposed individuals can
develop a keloid after any level of skin trauma, such as surgery, piercing, tattooing, bugbites, burns,
and so on. Rare genetic syndrome such as Rubinstein Taybi and Goeminne syndrome, can also
improve the chance of development in dark skinned people. TGF-?1 may have a key role in the
keloid formation. Many surgical and non-surgical therapy approaches have been researched and
proven to be helpful; however, none have been proven to be totally satisfying or perfect for all keloid
subtypes. Clinicians are up against a formidable obstacle as a result of this. When compared to
monotherapy, a combinatorial therapeutic approach often appears to provide the best results with
higher patient satisfaction. We examine the literature and sum up the general concepts behind the
various treatment procedures in this study like use of corticosteroids, verapamil, silicone-based
products, cryotherapy, imiquimod, 5-fluorouracil, laser therapy, mitomycin C, surgical excision,
interferons, bleomycin, radiotherapy, etc. In this field, more knowledge and understanding are needed
to give optimal therapeutic regimen for keloids.
Keywords: Keloid, TGF-?1, Rubinstein Taybi, Goeminne syndrome, Silicone, triamcinolone acetonide (TAC)
Publication date: 01/01/2023
https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6772.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.1.6772
