PIPERINE: PHYSICOCHEMICAL ASPECTS FOR LUNG CANCER Authors: Tandi DY , SAHU P, SHARMA H, NEMA RK AND SAHU GK*
ABSTRACT
Alkaloids are a group of chemical compounds root in nature that are chiefly made up of basic
nitrogen atoms. Piperine is an alkaloid found in black pepper (Piper nigrum), one of the most
often used spices, as well as long pepper (Piper longum) and other Piperaceae species fruits.
Piperine is culpable for the distinctive biting quality of black pepper. Piperine provide a
heterogeneity of pharmacological effects and health advantages, including the reduction of
insulin resistance, anti-inflammatory properties, and the alleviation of hepatic steatosis. Piperine
has been shown to limit the growth and survival of many different types of cancer cells by
activating apoptotic signals and inhibiting cell cycle progression. Piperine is known to have a
number of additional effects on cancer cells, including altering redox homeostasis, limiting CSC
self-renewal, and modulating ER stress and autophagy. Piperine inhibits invasion, metastasis, and
angiogenesis via altering the activity of numerous enzymes and transcription factors. Piperine is a
powerful p-glycoprotein (P-gp) inhibitor that has a considerable impact on the drug metabolising
enzyme (DME) system. Piperine can overcome multidrug resistance (MDR) in cancer cells and
functions as a bioavailability enhancer for many chemotherapeutic drugs due to its negative effect
on P-gp activity. The purpose of this review is to summarise the effects of piperine in chronic
conditions, either alone or in combination with other medications and phytochemicals. In this
review, we will discuss the concept of cancer chemoprevention and analyse recent advances in
piperine's chemopreventive action at the molecular, cellular, and organism levels, which can aid
in the design of future studies and the exploration of new molecular targets for therapeutic
intervention.
Keywords: Piperine, antidepressant effects, bioavailability booster, insulin resistance Publication date: 01/01/2023 https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6770.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2023/12.1.6770
