ABSTRACT

Nanoparticles provide a broad range of applications due to their site-specific action and sustained release of drugs. Several drugs loaded nanoparticles proved the local and systemic action by site- specific delivery of drugs. Chitosan nanoparticles act as potential drug carriers due to their biocompatible, biodegradable and non-toxic properties. Different techniques like ionic gelation prepare chitosan nanoparticles, coacervation, spray drying, emulsion crosslinking, reverse micellar, sieving methods. Sodium tripolyphosphate is used as a chemical crosslinking agent in the preparation. Drug loading in chitosan nanoparticles is carried out by incorporation or incubation. Release of drug from chitosan nanoparticles is governed by diffusion through the swollen matrix, release from the surface of particles, and release due to polymer erosion. Particle size, morphology, and surface properties are evaluated by transmission electron microscopic and scanning electron microscopic studies. Chitosan nanoparticles has a potential application in different drug delivery systems owing to its sustained release properties making them essential in recent nanoparticle studies. Chitosan nanoparticles are used as a delivery system for most of the antibacterial drugs such as Vancomycin, Cephalexin, Levofloxacin, Ampicillin, Ciprofloxacin and so on for their high efficacy and sustained release. The literature study has confirmed the increased efficacy of antibacterial drugs in the combination of chitosan nanoparticles. Keywords: Polymer Nanoparticles; Chitosan; Sodium Tripolyphosphate; Ionic gelation Method; Crosslinking; Antibacterial
Publication date: 01/01/2023

https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6767.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.1.6767