ABSTRACT

Adolescent depression is a prevalent mental health problem, with a prevalence of 4–5% in mid-to-late adolescence [1]. It is a significant risk factor for suicide, as well as social and educational difficulties. As a result, it's critical to recognise and treat this condition. In drug production for depressive disorder, an important approach is needed to resolve the current drug's side effects. Hence, the development of novel antidepressant models is a pressing need in biomedicine. The psychopharmacological function of linochiavalen emulsion has been demonstrated in zebra fish, an aquatic species with high sensitivity in screening antidepressants against Phobia induced depression. In this study, 5 groups of 15 fish in each group were separated, and depression was induced by exposing the fish to the dark environment for 7 days, followed by the treatment with 1 % and 2% Linochiavalen emulsion (5ml/litre) to the fish tank for next 5 days , Citapralom (5 mg/litre) taken as standard. Behavioural parameters like- Circling movement, number of top enteries, and freezing episode are monitored. The spectral analysis results showed that there was no chemical reaction between the oils, and also the phytomolecule Omega 3 faaty acid basic functional groups were confirmed through the FTIR analysis, then the antioxidant assay by DPPH method was found to be 500?g/ml. The emulsion-treated group's behavioural parameters were successfully reversed from the depression- induced group, and the histopathological test further confirmed the efficacy of the emulsion. Overall research concludes that the emulsion has good impact on stress induced depression. Keywords: Linochiavalen emulsion, Anti-depression, FT-IR Spectral analysis, DPPH assay, Zebrafish
Publication date: 01/01/2023

https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6766.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.1.6766