Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD),
which is associated with increased morbidity and death. Moreover, in affluent countries, the
prevalence of DN is steadily rising. Many rodent models of type 1 and type 2 diabetes have
been developed in order to better understand the pathophysiology of diabetes and test new
treatments for DN. Chemical, surgical, genetic, pharmacological, and diet/nutrition
interventions, as well as a combination of two or more methods, are used to create these
models. An animal model of DN should show the basic hallmarks of DN, such as a loss in
renal function, albuminuria and mesangiolysis, mesangial enlargement, and nodular
glomerulosclerosis. However, a rodent model of human DN with all of the aforementioned
characteristics has yet to be developed. Furthermore, in terms of albuminuria and the
development of glomerular and tubulointerstitial lesions, mice of various genetic
backgrounds and strains demonstrate varying levels of vulnerability to DN. As a result, the
type of diabetes, the progression of nephropathy, the length of the study, the expense of
maintaining and breeding, and the death rate of the animals are all key elements that could be
influenced by the DN model. The advantages and disadvantages of various diabetes rodent
models used to research DN are discussed in this review.
Keywords: Diabetes, Nephropathy, rodent model, albuminuria, mesangial matrix
expansion, tubulointerstitial fibrosis
Publication date: 01/01/2023
https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6754.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.1.6754
