ABSTRACT

More than 60% of drugs are poorly water-soluble, and it has less bioavailability. There are many techniques to overcome these problems, like Cyclodextrins, salt formation, lipid-based formulation, and solid dispersion. Amongst all approaches, supersaturable self micro emulsifying drug delivery system has been demonstrated to enhance oral solubility and bioavailability effectively. Supersaturable formulations are exposed to gastrointestinal fluids, the medication concentration exceeds equilibrium solubility. High medication concentrations improve oral absorption of poorly water-soluble medicines in this way. Nevertheless, since many drugs are thermodynamically unstable at high concentrations, they precipitate rapidly in vivo before getting absorbed, resulting in poor bioavailability. Precipitation inhibitors are widely valuable for enhancing solubility, absorption rate, and bioavailability in various formulations. This review article provides information about various polymers used in supersaturation effects on self-micro emulsifying drug delivery systems (SMEDDS). Keywords: Supersaturable, SMEDDS, solubility, bioavailability, solid SMEDDS
Publication date: 01/01/2023

https://ijbpas.com/pdf/2023/January/MS_IJBPAS_2023_6726.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.1.6726