ABSTRACT

Azilsartan, is a selective AT1 receptor blocker (Figure 1) that binds tightly and slowly separates [1], thus preventing the binding of angiotensin II leading to vasodilation and minimized aldosterone effects. The present study was aimed to develop a nanoparticulate drug delivery system of antihypertensive drug Azilsartan using polymer (poly vinyl alcohol). The prepared formulation were characterized for loading efficiency, entrapment efficiency, particle size, particle size distribution , zeta potential and drug polymer compatability studies. The entrapment efficiency of the optimized formulation F7 (drug 50mg, polyvinyl alcohol 75mg, ? –cyclodextin 10 mg) was 99.38 ±0.08 and invitro drug release was 98.46% after 24 hours. It also obey the zero order, follows diffusion and erosion mechanism of release. Surface morphology of optimized formulation (F7) indicated that lrbesartan nanoparticles were found to be in average nanometer range(358.4nm) and showed ideal surface morphology. The stability test performed revealed that the formulation (F7) showed no change in its characters. The optimized formulation (F7) was also examined for zeta potential determinations. Keywords: Nanoparticles, Azilsartan, optimization, Drug release
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6689.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.12.6689