ABSTRACT

Background: In periodontal disease variety of molecules are considered to mediate the inflammatory response including free radicals and reactive oxygen species (ROS). Periodontal pathogens can induce ROS overproduction and thus may cause collagen and periodontal cell breakdown. When ROS are scavenged by antioxidants, there can be a reduction of collagen degradation. Ubiquinone (reduced form coenzyme Q10) serves as an endogenous antioxidant which increases the concentration of CoQ10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation. Aim: To compare and evaluate intrasulcular application of commercially available Coenzyme Q10 gel with scaling and root planing in the treatment of Chronic Periodontitis patients as assessed through an advanced diagnostic aid, the Florida probe system. Materials and Methods: 30 Chronic Periodontitis patients with 30 sites have been selected and categorized randomly into 2 groups by lottery system for split mouth study with two parallel arms. Control sites were treated with scaling and root planing (n=30) and test sites were treated with scaling and root planing along with intrasulcular application of commercially available CoQ10 gel (n=30). Clinical parameters like plaque index, gingival index, bleeding on probing, periodontal probing depth, clinical attachment level was evaluated. Results were compared statistically using Students’ paired T test, at baseline and after 1 month and 3month intervals. There was a statistically significant improvement in gingival index and reduction in probing depth in test sites seen at the end of 3-months. Sites with bleeding on probing were reduced more in the test group than in control. Conclusion: Coenzyme Q10 can be said to have a beneficial effect on periodontitis when used as an adjunct to scaling and root planing. Keyword: Periodontal disease, Antioxidants, Coenzyme Q10, Local drug delivery, Periodontitis
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6680.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.12.6680