ABSTRACT

Objectives: The present study was undertaken to establish the diuretic, saluretic and hypoglycemic potential of aqueous extracts of Abelmoschus esculentus (L.) Moench fruits in rats. Methods: The selected male Sprague-Dawley rats were divided into different groups (n=6) and for evaluation of diuretic and saluretic activity, animals loaded with normal saline (10 ml/kg). Animals received Abelmoschus esculentus at 100, 200 and 400 mg/kg, po respectively and estimated urine volume (in ml) and content of Na+ , K+ & Cl- were measured in the urine of rats after 5th hour. For evaluation of hypoglycemic activity, alloxan induced diabetic rats were selected and estimation of hypoglycemic activity, animals treated with aqueous extracts of the Abelmoschus esculentus received 100, and 200 mg/kg, po respectively for 10 days. The blood glucose levels were estimated on day 0, 3, 6 and 10 day. Results: There were statistically a significant difference (P<0.05), in the urinary output shown by aqueous extracts of Abelmoschus esculentus at 200mg/kg and 400mg/kg and Furosemide (10mg/kg). Aqueous extracts have showed significant increments in urinary excretion of Na+(P<0.05), K+ (P<0.05), Cl- (P<0.05) when compared with control group after 5 hours and animals have also shown significant decrease (P<0.05) in blood glucose levels with increased period of exposure to the extracts. Conclusion: The study suggests that the aqueous extracts of Abelmoschus esculentus induce diuretic, saluretic and hypoglycemic response that will helpful in a various chronic diseases like hypertension, diabetes and metabolic syndrome. Keywords: Diuretic, Diabetic Mellitus, Okra, Furosemide, and Metabolic Syndrome
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6678.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.12.6678