ABSTRACT

Introduction: Various enzymes are released from host cells during the initiation and progression of periodontal disease. Alkaline Phosphatase (ALP) is an enzyme found in cells of the periodontium, including osteoblasts, fibroblasts and neutrophils. Studies show that concentrations of this enzyme in gingival crevicular fluid (GCF) from diseased sites are significantly higher than healthy sites. The injured tissues secrete alkaline phosphatase from the neutrophil that causes destruction of connective tissues. Aim: Present clinical study was undertaken to investigate a possible correlation between serum ALP levels in periodontitis with type 2 diabetics and non-diabetics subjects. Materials and Methods: In the present study 160 subjects were taken in the range of 30-70 years. Among these Group A comprised of 40 healthy subjects. Group B comprises 40 type II Diabetes Mellitus subjects with Periodontitis. Group C comprises of 40 type II Diabetes Mellitus subjects without Periodontits and Group D comprises of 40 periodontitis subjects without type II Diabetes Mellitus. The baseline of clinical examinations included measurement of clinical attachment loss, oral hygiene index-Simplified and Russel’s periodontal index. Laboratory measurements include serum alkaline phosphatase. Results: Serum alkaline phosphatase level was significantly raised in type 2 diabetes mellitus subjects with or without periodontitis and non diabetic subjects with periodontitis when compared to controls. Conclusion: From this study it was concluded that there is a positive correlation between chronic periodontitis and serum alkaline phosphates level in type 2 diabetes mellitus individuals which has been revealed by statistical analysis. Keywords: Serum Alkaline Phosphatase, Chronic Periodontitis, Type 2 Diabetes Mellitus, Russel’s Periodontal Index
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6674.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.12.6674