ABSTRACT

Due to present days heavily stressed lifestyle, the peptic ulcer has become a common disease to most of the people. The aim of this research is to evaluate a preclinical study of hydro-alcoholic extract of Lannea coromandelica leaves for its anti-ulcer activity on albino Wistar rat. Hydroalcoholic extract of Lannea coromandelica leaves was evaluated for its anti-ulcer activity using Ulcer model by Pyloric Ligation Method, Stress-Induced Ulcer Model, and Aspirin-Induced Ulcer Model. After extraction with 16.27% yield, the extract was assayed for its anti-ulcer activity. In the pyloric ligation method, Lannea coromandelica leaf extract of different doses like 250mg/kg and 500mg/kg showed significant levels of protection. In the Stress-Induced Ulcer Model, the animals were made to go through continuous stress of 4 hours by water immersion technique and here Lannea coromandelica leaf extract of the low and high dose showed remarkable protection levels. In the Aspirin Induced Ulcer Model Lannea coromandelica leaf extract of the low and high dose had provided notable ulcer inhibition parameter in respect of Ranitidine which is a marketed anti-ulcer drug. The anti-microbial and anti-oxidant properties of Lannea coromandelica could be responsible for its anti-ulcer property. Keywords: Hydro-alcoholic extract, anti-ulcer, Pyloric Ligation Method, Stress-Induced Ulcer Model, AspirinInduced Ulcer Model, Ranitidine, anti-microbial, anti-oxidant
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6634.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.12.6634