ABSTRACT

Bacteriocin is a term that refers to the proteinaceous substances produced by Gram-positive and Gram-negative organisms that bears antimicrobial properties. Bacteriocins are notably different from antibiotics by their structural features and activity. Since bacteriocins are proteins, they are ribosomally synthesized and exhibit narrow-spectrum activity and works on the same or near related species. Antibiotics are secondary metabolites produced through complex pathways catalysed by varieties of enzymes and demonstrate a broad spectrum of antimicrobial activity. Lactobacillus sp. is found to be major producers of bacteriocin which is most commonly used in the food industry. Nisin is an example of bacteriocin that is approved and worldwide accepted for utilization in the food industry. Looking at the currently applied aspect of bacteriocin, it is not limited to one or two industrial sectors. In addition to the food industry, bacteriocins are also found to have potential in health care especially skincare to treat acne. Bacteriocins that inhibit DNA synthesis can also have promising applications in cancer therapy due to their mode of action, which does not allow the growth of other carcinogenic cells. Keywords: Bacteriocin, LAB, Lantibiotic, Nisin, Antibiotics, Peptide antibiotic
Publication date: 01/12/2022

https://ijbpas.com/pdf/2022/December/MS_IJBPAS_2022_6621.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.12.6621