ABSTRACT

To develop nano-liposomal gel of methanolic extract of Pterocarpus santalinus for its antiinflammatory action. Formulation of various excipient combination of liposomes were formulated by using the thin film hydration method. Nine formulations (F1-F9) were designed and prepared by varying the concentrations of cholesterol. The formulation was further tested for their physical characterization like particle size, entrapment efficiency, % drug release and SEM. Stability study of optimized formulation was performed at refrigerated condition. Gels were prepared by incorporating Carbopol 940 as gelling agent and eucalyptus oil as permeation enhancer. The prepared gel formulations were assessed for various properties such as particle size, pH, spreadability, extrudability, viscosity, zeta potential, anti-inflammatory activity. Formulation of liposomes F5 was found to be optimal which was based on the entrapment efficiency in range 92.7 ± 2.08% with a desired mean particle size distribution 495.9 nm. Developed liposomal gel of Pterocarpus santalinus could have great effect for the anti-inflammatory treatment. Keywords: Pterocarpus santalinus, liposomes, anti-inflammatory activity, gel
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6611.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6611