ABSTRACT

Ophthalmic drug delivery system is one of the most challenging aspects with respect to drug delivery as human eye consists of tremendous barriers and this result into certain problems like low bioavailability which overall reduce the efficacy of the treatment. In Situ gelling system is considered as a unique method which is developed in order to increase the bioavailability of drug as well as to achieve a controlled manner of drug delivery. These are the gelling system which is liquid at room temperature but once, these are instilled into the human eye, they get modified into gels which involve different mechanisms like changes in temperature, pH or ionic environment. The present review focuses on the use of biodegradable polymers that are being employed in the formulation of this gelling system and their wide acceptability in designing of this system. Keywords: Ophthalmic, In Situ Gel, Natural Polymers, Bioavailability
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6601.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6601