ABSTRACT

Melatonin has a great potential towards the treatment and prevention of neuroinflammationassociated neuro-disorders. This systematic review aims to determine the various effects and activities exhibited by melatonin in a human neuroblastoma cell line like SH-SY5Y. As per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) parameters, this systematic review was performed by employing electronic databases like PubMed, Science Direct, and Google Scholar, to choose articles, which evaluated the anti-inflammatory activities of melatonin on SH-SY5Y. 11 studies were chosen from 11,836, which met the parameters of the inclusion criteria and were included for this systematic review. All studies considered proved melatonin’s potential against neuroinflammation by showing anti-inflammatory effect in the treated SH-SY5Y cell line. Keywords: Melatonin, neuroinflammation, NF-?B, SH-SY5Y, systematic review
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6600.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6600