ABSTRACT

In this work, we have used a combination of stimuli responsive polymers, namely Chitosan ( Ch) and poly-N-isopropyl Acrylamide (poly(NIPAAm)),as a injectable liquid mixture to deliver the entrapped anti-cancer drug Cis-Platin(CP) at the simulating tumor environment(STE), with minimum drug release in the blood environment. A solution, containing Ch, poly (NIPAAm) and CP was exposed to simulating blood environment (SBE) and then to the simulating tumor environment (STE) at 370C. It was found that injectable liquid mixture was co-precipitated with minimum release in SBE while a 14 times higher release was observed in STE, thus indicating that liquid mixture was successful to deliver most of the drug at the tumor site with minimum release in the blood stream. The combination of chitosan and poly (NIPAAm) appears to be a injectable system that could undergo sol-gel transition on exposure to pH and/or temperature variations. Keywords: Cancer, Tumor, injectable hydrogels
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6599.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6599