ABSTRACT

Naproxen is a potent non-steroidal anti-inflammatory drug but it is insoluble in water. Formulation of naproxen as emulgel improves its solubility. The aim of the study was to formulate and evaluate naproxen-loaded emulgels produced using Moringa oleifera seeds oil. Moringa oleifera seeds were dried, ground and the oil extracted with petroleum ether using a Soxhlet extractor. The oil was concentrated using a rotary evaporator. Emulsion was formed by mixing the oil and the aqueous phase at 70oC. The aqueous phase was composed of tween 80, methyl paraben, propylene glycol and naproxen. Sodium carboxymethylcellulose was dispersed in warm water and stirred to form gel. The emulsion was gradually added to the sodium carboxymethylcellulose gel base to produce the emulgel. The emulgels were evaluated for physicochemical, analgesic and anti-inflammatory properties. The prepared naproxen emulgels were white to creamy white and opaque in appearance. The pH of emulgels ranged from 5.00±0.04 to 5.85±0.01. The emulgels have good spreadability, extrudability, homogeneity and did not cause skin irritation. They showed good analgesic and anti-inflammatory activities. The study showed that Moringa seed oil could be used to produce naproxen-loaded emulgels with acceptable physicochemical, analgesic and anti-inflammatory properties. Keywords: Emulgel, naproxen, Moringa oleifera, spreadability, analgesic, anti-inflammatory
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6578.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6578