ABSTRACT

Liver-related diseases have become a global concern worldwide. Hepatic cells damage is mostly caused by a variety of toxic chemicals like carbon tetrachloride (CCl4), acetaminophen (APAP), antibiotics and thioacetamide. For the treatment of liver diseases herbal based therapeutics has been used from long time in India and has become popular all over world by leading pharmaceuticals. But in some places herbal medicines are still not acceptable for the treatment of liver diseases due to its limiting factors. V. vinifera have numerous medicinal properties such as it acts as vasoprotective, astringent, diuretic and hepatoprotective activity. Due to favorable properties such as easy to design, easy to prepare, interesting biomimetic, a variety of structure and have good biocompatibility, polymers are used as biomaterials. Polymeric nanoparticles can be used as the hepatoprotective agent due to their unique properties. In this present study we used V. vinifera loaded polymeric nanoparticle as hepatoprotective agent which can be used as a good therapeutic agent against liver toxicity and also for the successful development of drug delivery in near future. Keywords: Acetaminophen (APAP), V. vinifera, hepatoprotective, therapeutic agents, liver toxicity
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6561.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.11.6561