ABSTRACT

The most worldwide cause of non-genetic sensory deafness in children is Cytomegalovirus (CMV), which is also the most mutual cause of congenital infection. CMV spreads horizontally by close contact with biofluids such as urine, breast milk, saliva, and sexual excretions. Pneumonia, nervous system issues such as brain inflammation (encephalitis), and digestive system issues such as colon (colitis), esophageal (esophagitis), and liver (hepatitis) inflammation are all possible side effects of CMV infection. As a result, a CMV infection must be recognized and treated. The early diagnosis of immunosuppressed persons with CMV illness, as well as neonates and babies with congenital CMV infection, stimulated the discovery of innovative diagnostic techniques for the rapid recognition of immunosuppressed individuals with CMV disease. CMV infection is diagnosed using particular antibodies and molecular testing. The Identification of acute maternal CMV infection needs the presence of IgM and a low IgG avidity. CMV PCR of the amniotic fluid is usually used to approve fetal infection. Serological assays are executed to detect IgG antibodies, with the Enzyme-linked immunosorbent assay (ELISA) being the most widely used technique. The latest available methods of CMV infection are highlighted in this review article. Keywords: Cytomegalovirus(CMV), Congenital infection, Polymerase chain reaction(PCR), Enzyme-linked immunoassay(ELISA), Antigenemia assay
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6560.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6560