ABSTRACT

Titrimetric method for determination of furosemide in bulk drug and formulation is described here. In this method, solution of furosemide using different inorganic solvents were titrated against alkaline solution of sodium hydroxide using bromothymol blue as an indicator by mixed co-solvency process. The method was validated and the statistical evaluation of method was performed by inter-day and intraday precision. The accuracy and reliability of the proposed method was ascertained by comparison with a reference method. This method is beneficial over the reported methods for estimation of furosemide tablets in such a way that here we are using inorganic solvents in place of organic solvents and thus the toxicity of solvents is decreasing. Inorganic solvents are cheap as compare to organic solvents that’s why the method is cost effective. Keywords: “Furosemide”, “Mixed co-solvency process”, “Titrimetric analysis”, “Validation Parameters”
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6559.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6559