ABSTRACT

Vitiligo is a pigmentary autoimmune disorder of the skin affects 1-2% of world population. Oxidative stress is one of the causes for vitiligo resulting in melanocyte degeneration, hydrogen peroxide (H2O2) accumulation in the epidermis and an insufficient antioxidant system with increased levels of reactive oxygen species (ROS). Superoxide dismutase (SOD) protects cells from toxic effects of superoxide radical. Malondialdehyde (MDA), an endproduct of lipid peroxidation induced by ROS. The aim of this study is to compare the levels of serum SOD and serum MDA among newly diagnosed vitiligo patients and healthy people and to study the correlation between serum SOD and MDA levels in vitiligo. It is a cross sectional study, where 40 newly diagnosed vitiligo patients as study group and 40 healthy people as controls aged between 14-50years were included . Serum SOD and MDA were estimated and statistical analysis was performed. p value of < 0.05 is considered significant. The Mean ± SD of serum SOD (u/ml) (0.75± 0.24) in study group were significantly lower than controls (1.64 ± 0.72). The level of serum MDA (nmol/dl) in vitiligo patients (103.61 ±17.84) were significantly higher than controls (83.36 ± 9.72; p<0.0001) and there was a statistically significant correlation between serum SOD (u/ml) and serum MDA (nmol/dl) among vitiligo patients (P value < 0.001). Our study demonstrate that there was an impairment in the oxidant/ antioxidant balance in vitiligo. So the markers of oxidative stress can be employed to assess disease activity and to plan and monitor antioxidant therapy. Keywords: Vitiligo, Oxidative stress, Serum malondialdehyde (MDA), Serum superoxide dismutase (SOD)
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6557.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6557