HBV infection is a highly still a major hazard to health issues all around the world and It can
cause liver illnesses. The Diagnosis of HBV patients, both acute and chronic, It is a critical step
in minimizing the infection’s impact. One important way to reduce the impact of the disease is to
serological diagnosing using biomarkers is to detect antigens and antibodies against these virus
such as HBs Ag (Hepatitis B surface antigen), HBs Ab (Antibody to HBV surface antigen), HBc
Ag (Antibody to HBV core antigen), HBe Ag (Hepatitis B e antigen), Anti-HBe (Antibody to
HBV e antigen), Anti-HBc (Antibody to HBV core antigen), HBcr Ag (Hepatitis B core-related
antigen) and advance serological techniques are such as Enzyme-linked immunosorbent assay
(ELISA), Western Blot, Chemiluminescent Enzyme Immunoassay (CLEIA), Rapid test, Microparticle Enzyme Immunoassay (MEIA). Quantitative and qualitative molecular tests are utilized
to confirm a primary diagnosis, measure the viral load, detect genotypes, and resistance
mutations, and molecular techniques are including such as Polymerase chain reaction (PCR), Biosensor and paper based analytical device are needed for effective diagnosis of HBV infection.
The most recent available serological and molecular techniques for diagnosing HBV infection
are summarized in this review article.
Keywords: Hepatitis B virus (HBV), HBs Ag, HBe Ag, HBc Ag, HBcr Ag, HBV DNA,
Serological diagnosis, Molecular diagnosis
Publication date: 01/11/2022
https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6555.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.11.6555
