A REVIEW ON MONONUCLEAR GOLD(III) PORPHYRIN COMPOUNDS AS ANTICANCER AGENTS Authors: Satapathi S
ABSTRACT
In the last decade gold based metallodrugs show the significant role in the progress of medicinal
chemistry for therapeutic and diagnostic purpose especially in the treatment of cancer,
chrysotherapy, SARS-CoV-2 virus, HIV and other diseases. Though gold compounds with +1
and +3 oxidation states are dominant in medicinal chemistry, predominantly gold(III) compounds
have attracted special attention for their structural similarity with the most extensively used
anticancer metallodrug cisplatin. Several mononuclear anticancer gold(III) porphyrin compounds
show significant antiproliferative properties in vitro against certain human tumor cell lines and
can overcome cisplatin resistance where the macrocyclic ligand plays a vital role in their
anticancer activity. The aim of this review is to sum up the chemistry and anticancer activity of
some novel mononuclear anticancer gold(III) porphyrin compounds that making themselves
excellent candidates for future pharmacological evaluation. The general viewpoint on the
development of these compounds as clinically effective anticancer drugs is deliberated here on
the source of the existing experimental evidence.
Keywords: Gold(III) ion; porphyrin ligand; Mononuclear compounds; Chemistry and
Anticancer activity Publication date: 01/11/2022 https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6553.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2022/11.11.6553
