ROLE OF ALPHA AMYLASE INHIBITOR IN DIABETES MELLITUS Authors: Navik P , TOMAR RS AND SHRIVASTAVA V*
ABSTRACT
The prevalence of diabetes mellitus globally and in the Indian subcontinent has become
a serious medical and pharmacological issue that needs to be managed and prevented as
it has become the major cause of death due to the complications associated with this
disorder. The commercial anti-diabetic medications with alpha-amylase inhibition
property presently in clinical use has several side effects which led to the finding of
natural antidiabetic agents or alpha-amylase inhibitors from various plants extracts that
are known for medicinal properties. The antidiabetic agents used are alpha-amylase
inhibitors that act upon alpha-amylase enzyme which is involved in the digestion of
dietary starch and delays the glucose release in the blood after the meal and thus
prevent postprandial hyperglycaemia. The antidiabetic agents from plant extracts are
known to be the best and safer therapeutic approaches for the prevention and
management of diabetes mellitus and postprandial hyperglycaemia. In this review,
various natural plant extracts and phytochemical compounds used in the treatment of
hyperglycaemia via alpha-amylase inhibition as an antidiabetic agent are discussed.
Keywords: Alpha amylase, Diabetes Mellitus, Alpha amylase inhibitor, postprandial hyperglycaemia Publication date: 01/11/2022 https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6547.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2022/11.11.6547
