ABSTRACT

Versatile biological activity profile of the benzoxazinone scaffold attracted the medicinal chemists to explore lead molecules for the treatment of various microbial diseases. Extended literature avowed the indisputable antimicrobial properties of thiosemicarbazones that stimulated us to the current exploration. Synthesis of novel benzoxazinonethiosemicarbazone (5a-5c) hybrids from the condensation of substituted anthranilic acid (1a1c), with acetyl chloride (2) to methyl bzoxazine-4-ones (3a-3c) that are oxidized using selenium dioxide to the corresponding aldehydes(4a-4c) followed by the condensation with various thiosemicarbazides. Fifteen novel benzoxazinone-thiosemicarbazone (5a1-5a5, 5b1- 5b5&5c1-5c5) were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support. The titled compounds were screened for antibacterial and antifungal activities. Results proclaimed that all the synthesized compounds were exhibiting antimicrobial properties. Compound5b4 was contended to bear potent antimicrobial properties against the given bacterial and fungal strains. Keywords: Benzoxazin-4-one, Thiosemicarbazone, Antibacterial, Antifungal, Agar disc diffusion
Publication date: 01/11/2022

https://ijbpas.com/pdf/2022/November/MS_IJBPAS_2022_6109.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.11.6109