ABSTRACT

Numerous drugs available in the market are poorly water soluble. Majority of the failures in new drug development are because of the poor aqueous solubility of the drug. The present study illustrates the application of hydrotropic solubilization technique to increase the solubility of poorly water-soluble non-steroidal antiinflammatory drug, ibuprofen. Sodium salicylate (2M) and sodium acetate (2M) solutions were employed as hydrotropic solubilizing agents to solubilize the ibuprofen to facilitate its titrimetric analysis, excluding the use of organic solvent. Solubility study exhibited enhancement of solubility of a drug in 2M sodium salicylate and sodium acetate solutions as compared to solubility in water. The drug was analyzed successfully. The results of analysis obtained by employing the proposed method involving the use of hydrotropic agents were found to be very close to the results of the standard Indian Pharmacopoeial method. The proposed method was validated statistically which proved the accuracy, precision, and reproducibility of the method. Keywords: Hydrotropy, Ibuprofen, Sodium salicylate, Sodium acetate, Titrimetric analysis
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6518.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6518