ABSTRACT

The formulation and evaluation of herbal and synthetic polymer-based microspheres for a targeted drug delivery, herbal polymer arrowroot is effectiveness, biodegradable, polysaccharide, and natural polymers chitosan is used in preparation and comparison as a (standard natural polymer) polymer-based microspheres and establishment of arrowroot microspheres. Several drugs delivery system for targeting the organ and tissue, the drug release provides a therapeutic effect of drugs and desired concentration in the body. Naturally polymers-based microspheres are used as a carrier system for a targeted tissue, organs and used to effective manner. These are consisting of protein, natural and synthetic which are biodegradable floras, particle size having less than 200 ?m. It is prepared by solvent evaporation methods and cross-linking methods. Arrowroot-based ethyl cellulose microsphere is prepared by solvent evaporation technique using ethyl cellulose and poly vinyl alcohol (stabilizer). The prepared microspheres are tested for particle size, percentage entrapment efficacy, zeta potential, and in vitro drug release. Controlled /sustained drug delivery system provides, minimize the side effect of conventional drug delivery, and increase the therapeutic efficacy of drug. The various applications of this microsphere, such as cancer cell and colon targeted drug delivery system, are critical for the safe and effective in-vivo drug delivery. The goals of this study are to highlight some key aspects of herbal microspheres as a novel drug delivery system. It was determined that the developed herbal microspheres formulation is a significant, therapeutically effective, and cost-effective vehicle for drug delivery. Keywords: Arrowroot Polymer, Chitosan, ethyl cellulose, Solvent evaporation, Microsphere’s drug delivery system
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6510.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6510