ABSTRACT

The Ezetimibe (EZE) drug has a good ambiance in lowering blood cholesterol and is most advanced and useful for the pharmaceutical formulations, and also in the method validation which is validated according to ICH guidelines, very simple different estimation techniques were used to analyze for routine use of analysis for quality control, and for the tablet dosage form. Ezetimibe well interacts with all analytical techniques and also with the combined dosage form. In LCMS, the liquid extraction is removed, the analyte and inner standard were isolated, and the concentrations were analysed accurately in human plasma. In HPLC, the crude samples contain impurities and ezetimibe were hydrolytic for degradation products, In UV, the absorption spectra of the peak concentration stays constant. The experiments prove that all the accurate values in all analytical techniques were achieved for the successful use of the pharmaceutical dosage form. Therefore, the ezetimibe (EZE) drug is affiliated to all kinds of analytical techniques with an accurate range of concentrations. Keywords: ezetimibe, analytical method, pharmaceutical formulations
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6507.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6507