ABSTRACT

A latest, uncomplicated, error – free, low-cost UV Spectrophotometric method has been flourished for the simultaneous estimation of Olmesartan medoxomil, Chlorthalidone, Amlodipine besylate in bulk and in combined tablet dosage form employing simultaneous equation method. The stock solution was composed by methanol followed by the further required with distilled water. This method involves the formation and solving of simultaneous equations at 256 nm, 227 nm and 237 nm, as absorbance maxima of Olmesartan Medoxomil, chlorthalidone and amlodipine besylate, respectively. Beer’s law obeyed the concentration range of 14-26 µg mL-1, 8.75-16.25 µg mL-1, and 10.5–19.5 µg mL-1, for Olmesartan Medoxomil, Chlorthalidone and Amlodipine besylate respectively. The results of analysis were validated for various parameters according to ICH guidelines. Keywords: UV Spectrophotometric, Olmesartan medoxomil, Chlorthalidone, Amlodipine besylate, ICH guidelines, Simultaneous estimation
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6499.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6499