ABSTRACT

The main objective of this study was to develop self-nano emulsifying drug delivery system (SNEDDS) to enhance the oral absorption of the poorly water-soluble drug Docetaxel. The influence of the oil, surfactant and co-surfactant on the drug solubility and their ratios on forming stable SNEDDS were investigated in detail. The SNEDDS were characterized by morphological observation, droplet size, zeta potential measurement, freeze thawing and in vitro release study. The optimum formulation consisted of 40% Capryol 90, 20.66% Cremophor EL and 10.33% Polyethylene glycol 400. In vitro release test showed a complete release of Docetaxel from SNEDDS in an approximately 4 h. The absorption of Docetaxel from SNEDDS showed increase in absorption compared with that of the marketed formulation Taxotere. Our studies demonstrated the promising use of SNEDDS for the delivery of Docetaxel by the oral route. Keywords: Docetaxel, Self nanoemulsifying drug drlivery system, Pseudoternary phase diagram
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6491.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6491