ABSTRACT

Taro (Colocasia esculenta) has been reported to have 70-80% of starch which could play a vital role as a disintegrating agent in pharmaceutical tablet formulation. The purpose of the study was to extract and evaluate the starch from Taro (Colocasia esculenta), as well as to use taro starch as a disintegrating agent in tablet formulation. In this study starch was extracted from Taro by simple, wet milling and centrifugation process and physiochemical tests of the extract revealed that the starch extracted from wet milling showed better properties, while rendering no harm to the chemical composition of the extract which was then was used to formulate twenty placebo tablets by using direct compression, wet granulation as well as dry granulation for comparison study. The formulated tablets were evaluated by its hardness, friability, weight variation, solubility and disintegration time. Results from disintegration efficiency study showed that the tablets formulated from Taro starch disintegrated in 3 minutes out of which tablets formulated by wet granulation showed better properties when compared to tablets formulated by other methods. The reduced disintegration time along with the low weight variation showed that Taro starch as a better disintegrant compared to other natural starches for tablet formulation. Keywords: Taro starch, wet granulation, disintegration time, placebo tablets
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6486.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6486