ABSTRACT

For cancer treatment,nanotechnology has been extensively studied and exploited and in a drug delivery system it plays a significant role.To treat various cancers nanotechnology has been actively integrated as drug carriers. Nanotechnology is considered to be an emerging, disruptive technology that will retain a crucial impact in all industrial sectors. The investigation is recently started on the role of nanoparticles in immunotherapy which plays a most important role in cancer treatment. So nanocarriers have been increasingly used in drug delivery. By using nanoparticles, the off-target effects of such drugs can be improved, and also the cancer patients may have new hope. Utilizing nanoparticles to improve the therapeutic effect of chemotherapeutic drugs for enhancing the specificity and prolonging the circulation of life of drugs. By administrating nanoparticles, they show increasing in proliferation in tumour tissues near the blood vessels, enhancing both anticancer drug permeability and tumour retention. Compared to conventional drugs and nanoparticles-based drug delivery has certain benefits such as improved stability and biocompatibility, enhanced permeability, and retention effect. Nanoparticles applied to drug delivery systems include organic nanoparticles, inorganic nanoparticles, and hybrid nanoparticles. For cancer therapies, several nanocarriers are approved for clinical use and many novel formulations are in the later stages of clinical trials. The preclinical and clinical trials are evaluated for several nano-drug delivery systems designed for tumour targeting and they show reasonable outcomes in cancer tumour clinical management. Keywords: nanotechnology, drug delivery, drug resistance, hybrid nanoparticles
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6473.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6473