ABSTRACT

Background and objectives: The use of an ideal inducing agent for cervical ripening is necessary to prevent adverse maternal and fetal outcomes. The present study aimed to assess the efficacy and safety of prostaglandin E2 (PGE2) in the induction of labor among primigravida and multigravida women at a hospital in Karad. Materials and Method: A total of 110 primigravida and multigravida women were included in this observational study. Women were grouped into experimental and control groups with 35 primigravida mothers and 20 multigravida mothers each in both the groups. Subjects in the experimental group were subjected to intracervical application of PGE2. Results: A significantly higher proportion (p<0.001) of women in the experimental group had poor Bishop scores. The most common complication responsible for labor induction was postdatism in primigravida (37.1%) and multigravida women (50%). The induction failure rate was significantly low in primigravida (20%) and multigravida (5%) women who underwent PGE2 induction when in comparison with the control group. Mean duration from induction to delivery in primigravida was 9 hrs, 22 mins and 8 hr, 15 min in multigravida women. Nausea (primigravida=28.6%, multigravida=5%) and vomiting (primigravida=8.6%, multigravida=5%) were reported by significantly lesser number of primigravida and multigravida women in the PGE2 group Conclusion: Prostaglandin E2 gel is effective in inducing labor in primigravida and multigravida women, with a shorter induction to delivery time, and low incidence of maternal and fetal adverse effects. Hence, prostaglandins can be routinely administered for smooth induction of labor in primigravida and multigravida women. Keywords: Cervical ripening, Prostaglandin E2, Induced labor, Fetal outcome, Maternal outcome
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6472.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6472