ABSTRACT

The new development in Liquid chromatography- Mass spectrometery (LC- MS) is reviewed. This review includes a short history of LC-MS method, and explanation about different techniques like atmospheric pressure ionization (API), here ionization of the specified sample got ionized with respect to vacuum created and pressure inside the source after that the ionized ions pass to dector and quantities based by mass spectrometer, Microspray and Nanospray, Matrix effect, and microfluidics. For the purpose of qualitative and quantitative liquid chromatography-tandem mass spectrometery (LC-MS/MS) analysis, commonly using Atmospheric pressure ionization sources are Electro spray Ionizations (ESI) and atmospheric pressure chemical ionizations (APCI). Reduction in ESI gas load offers a few likely advantages in ion formation and ensuing mass analysis, and this review discuss about how micro/nano spray helps in the formation of stable spray. Keywords: Liquid Chromatography-Mass spectrometery (LC-MS), Electrospray ionization (ESI), Microspray, Nano spray, Matrix effect
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6458.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6458