ABSTRACT

LC – MS: Liquid chromatography – Mass spectroscopy, a rapidly growing as well asthe most chosen option in Pharmaceutical Analysis. The discovery of LC- MS is a milestone in biomedical research and in 1980s; the first LC-MS was presented. LC – MS (Liquid chromatography – Mass spectrometry) system is aunion of Liquid Chromatography (LC); High Performance Liquid Chromatography (HPLC) together with Mass Spectrometry. The LC – MS assumes crucial part in many fields. This review essentially centers on the principle, instrumentation and applications of LC-MS method. LC-MS isutilized in varioussteps of drug development counting Identification and stability screening of metabolite, Peptide Mapping, Identification of impurity, Mapping of glycoprotein, and Screening for bio affinity. LC-MS is also outstanding in numerous spaces, countingforensic toxicology and therapeutic drug monitoring (TDM). Keywords: LC-MS, HPLC, MS, Ionization Source, Mass Analyzer, Mrtabolomics
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6456.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6456