ABSTRACT

Protein mis-folding and aggregation is important in detecting early stage of neurodegenerative disease such as Parkinson and Alzheimer disease. Early detection may help in accurate treatment of the patient. With proper treatment, most individuals with neurodegenerative disease can lead long productive lives.Many a disease are associated with the aggregated protein and this then gets transferred from one region to another leading to lifetime impairment. This review article mainly focuses on the early detection of the accumulated proteins in the brains with the help of analytical techniques. When protein aggregates reach a certain level in the cell, they become toxic. The accumulation of abnormal proteins causes neurons to lose their structure and/or function over time, eventually leading to their death. Prion, Alzheimer's, Parkinson's, and Huntington's diseases are only a few of the diseases linked to protein aggregation. As a result, dysmnesia, mental retardation, and apathy are common. Much quantitative analytical technique can be used to detect aggregated protein by different mechanisms based on the methods used. Therefore, a basic understanding on neurodegenerative diseases which are caused due to aggregation of different types of protein in the brain can now be identified by analytical techniques in prior so that they can be treated and it won’t spread. So, we have covered all the analytical techniques which can be used in this field by determining whether he/she is suffering from neurodegenerative disease so that they can be treated on time. Keyword: Neurodegenerative disease, dysmnesia, analytical, protein, aggregation
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6452.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.10.6452