ABSTRACT

The primary goal of this investigation was to formulate and evaluate the fixed dose combination of tablets containing the montelukast 10 mg and levocetirizine 5 mg in tablet dosage form. Under the preformulation studies solubility, loss on drying, water content by KF, tapped density, and hygroscopic nature were carried out. This combination formulation was formulated by using various excipients hence that cause rate of drug release gradually enhanced. These studies showed satisfactory results for further formulation. This combination tablets were showing the effective results in various quality control parameters and dissolution profile and assay of the developed product also complies with the Indian Pharmacopoeial (IP) specification and inhouse specifications of Bal Pharma Limited. The result of the prototype formulation showed that the batch 5 and batch 6 produce effective drug release results and it is found to be more cost effective when compared to the existing formulation. Keywords: Montelukast, Levocetirizine, Drug Release, Asthma
Publication date: 01/10/2022

https://ijbpas.com/pdf/2022/October/MS_IJBPAS_2022_6448.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.10.6448