ABSTRACT

Objective: The aim and objectives of this research work carried out to evaluate the antidiabetic activity of ethanol extract of stems of Cassia javanica Linn. Methods: Aqueous extract of stems of Cassia javanica Linn studied on alloxan induced diabetic rats as two different doses were studied. Results: Both extract showed significant reduction in the blood glucose level. Concurrent histopathological examination of pancreas of these animals showed comparable regeneration by aqueous extracts (lower and higher dose) which were earlier, necrosed by alloxan. Conclusion: The Aqueous extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of ?-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Cassia javanica extracts, as a possible mechanism of their antidiabetic activity. Keywords: Antidiabetic activity, stems, Cassia javanica Linn, Alloxan induced diabetic, aqueous extracts, Glibenclamide
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6426.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6426