ABSTRACT

The formulation of Doxofylline buccal tablets was the primary goal of this research, which used different acceptable mucoadhesive polymers, such as Carbopol 934P and HPMC. An impermeable backing layer of ethyl cellulose was used. The direct compression technique was used to make six batches of doxofylline mucoadhesive buccal tablets. Physicochemical characteristics like tablet thickness, friability, drug content, weight variation, surface pH and swelling index were then assessed and in vitro dissolution test were also carried out in accordance with IP 2018. All of the prepared tablets were under the permitted limit as stated in IP 2018. The batch 1 (95.81 percent) guaranteed a long-term release of the medication and a proper swelling index (73.70 percent). Thus, the findings showed that doxofylline can be made into a buccal mucoadhesive tablet. Furthermore, the properties of the tablet are not only influenced by the concentration of the polymers, but also by their behaviour. Keywords: Doxofylline, Mucoadhesive Buccal tablet, Carbopol 934P, HPMC
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6422.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6422